The controversial discovery that our brains can generate new neurons surprisingly late in life is now prompting a rethink of adult brain health, pointing the way to better treatments for stroke, dementia and depression By Jamie Ducharme
Often described as a genius, physicist Sabrina Pasterski built and flew her own plane by the age of 16 and is now developing a mind-bending idea that could finally unify gravity and quantum theory By Miriam Frankel
MIT TECHNOLOGY REVIEW: The Impossible issue features ‘Is it fun to dream about living on the moon or uploading our brains?’ For sure. But questing after the impossible is about way more than pipe dreams. This issue explores what we can do when we have the audacity to push for our most daring goals, from synthesizing blood to building AI with real guardrails. Plus: A bionic eye, the AI companies training models with dead startups’ data, and more.
Some transformative technologies have been “coming soon” for years. We ran progress reports on six big ideas to see how close they are to reality.
We ran progress reports on six potentially transformative technologies and ideas that have been “just around the corner” for years or, in some cases, decades. We called up experts with a bird’s-eye view of the fields to get a sense of what’s holding things back, and we chatted with folks running the studies, crunching the data, and building the prototypes that could make these dreams into realities. Then we placed each idea on a progress meter ranging from 0 to 10—0 being “We don’t even know where to begin” and 10 being “We did it!”
We know that this monster El Niño will bring floods, droughts, cyclones and wildfires, but some governments aren’t putting in the necessary resources to prepare for disaster
This El Niño is forecast to end around June next year after smashing all records, but its impacts could persist indefinitely in some parts of the world By Michael Le Page
In the early 2000s, geneticists Helen Hobbs and Jonathan Cohen at the University of Texas Southwestern Medical Center launched an ambitious effort to investigate cardiovascular health in Dallas County. Their study was unusual for the time. Rather than largely focusing on people of European ancestry, the Dallas Heart Study deliberately recruited a diverse population that reflected the region’s demographics.
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Rare genetic changes in a gene called PCSK9 help control low-density lipoprotein (LDL) cholesterol, the “bad” cholesterol linked to heart disease.
People who naturally make less of the PCSK9 protein have much lower LDL levels, pointing researchers toward new possibilities for lowering cholesterol.
That insight led to a new class of cholesterol-lowering drugs and showed how studying diverse populations can uncover important clues about disease.
I spent much of my childhood in Colorado, which means that I, like millions of others living in the American West, grew up hearing warnings about the dangers of plague. People often find it shocking to learn that Yersinia pestis, the bacterium discovered in 1894 that is believed to have caused the mid-14th-century Black Death and other plague pandemics, is still around and dangerous, but that is one of many misperceptions about plague that need correcting. Plague’s multiple pandemics were not limited to the Black Death nor to Europe. And it is not a disease that disappears simply because no human cases are being reported at epidemic levels. Plague is not a thing of the past, and infections most definitely occur to this day.
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For centuries, our understanding of plague was riddled with assumptions based on a few historical accounts and data from modern plague victims.
Advances in genomics and bioarcheology now allow us to tie historical plague pandemics to human remains and even reconstruct the full plague family tree.
These data tell a new, broader story in which plague arrives earlier, stays later, and lurks in rural animal reservoirs before spilling over into human populations.
Seeking and evaluating explanations can shape the very process of learning. Just like tasting the soup as you’re cooking can shift the final product toward a closer approximation of soupy perfection, explaining as you learn can change the course of learning itself, pushing you to find a closer approximation of a truly great explanation: one that covers all the relevant observations in the simplest way possible. But how does that work?
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The process of explaining is a powerful learning tool.From a young age, humans ask “why”; answering that question can reveal deeper meanings and reveal hidden patterns.
Explaining can unlock abstraction, a complex thought process that allows people to generalize from specific examples to identify common themes.
The need to know why can unlock learning, but it can also drive some people to latch on to patterns that do not exist, such as conspiracy theories.
News, Views and Reviews For The Intellectually Curious
