Take an animated look inside the neuron, and learn how scientists are addressing brain disease. With approximately 86 billion neurons in the brain, humans contain the most complex communications network imaginable. To address diseases of brain development and degeneration, neuroscientists are investigating how and why this network breaks down, and what can be done to repair it.
One area of study is dendrites, which are the tree-like structures of neurons, that receive electrical impulses. Researchers are carefully mapping out brain circuits and uncovering how connectivity changes can result in defects of the visual system or behavioral problems. The core section of the neuron is the cell body. Genetic engineering tools are revealing how mutations impact brain development and contribute to autism spectrum disorder or rare, inherited forms of neurological disease.
The transmission of nerve impulses occurs along the axon, which is insulated, much like an electrical wire, by a fatty layer called the myelin sheath. Scientists have invented a medicine to stop the immune system from mistakenly attacking this layer, which occurs during multiple sclerosis. Other molecules currently in development instruct the body to regenerate the sheath and repair damage. The axon also transports valuable cellular cargo, such as neurotransmitters, along tracks from one end of the neuron to the other.
Researchers are testing drug candidates for their ability to remove molecular traffic jams when this transport system fails, as often occurs in Parkinson’s and Alzheimer’s disease. The axon terminals make connections called synapses with other cells, using neurotransmitters as signals. Some scientists are evaluating how finely tuning the receptors for these chemicals could ease depression and anxiety.
Others are finding ways to promote the regrowth of lost synapses, which could halt neurodegeneration. From genetics to behavior, neuroscience is accelerating new interventions for the most challenging disorders of the nervous system.
A medication prescribed for Parkinson’s and other diseases can transform a patient’s personality, unleashing heroic bouts of creativity or a torrent of shocking, even criminal behavior
Millions of people struggle with insomnia, but the sleep disorder is now a solvable problem – and the most effective therapy might involve your smartphone rather than sleeping pills
Rebecca Wragg Sykes on the objects that reveal the Neanderthal mind
A third of scientists working on AI say it could cause global disaster
What’s the best recipe for bubble mixture? Scientists have the answer
A family tree of sea cows suggests that the dugong traversed an ocean to reach its present habitat.
Builder drones
Ground-based robots have potential for helping in the construction industry, but they are limited by their height. In this week’s issue, Mirko Kovac, Robert Stuart-Smith and their colleagues introduce highly manoeuvrable aerial robots that can perform additive 3D construction tasks. Inspired by natural builders such as wasps and bees, the researchers created BuilDrones (as shown on the cover) that can work in an autonomous team to perform 3D printing tasks using foam- or cement-based materials. They also created ScanDrones to assess the quality of the structures
being built. The team hopes that this approach of ‘aerial additive manufacturing’ could help to build structures in difficult to access areas.
Seasonal monsoon rainfall replenishes groundwater reserves in the Bengal basin of Bangladesh thanks to the region’s seemingly counterintuitive intensive dry-season irrigation practices, a new Science study finds.
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