Category Archives: Health

New Study: Obesity Results In Six Times Higher Rates Of Type 2 Diabetes, 3X More Than Genetic Risks (2020)

From a Diabetologia online study release (April 15, 2020):

Diabetologia Journal“Having normal body weight is crucial in the prevention of type 2 diabetes, regardless of genetic predisposition.”

“The results suggest that type 2 diabetes prevention by weight management and healthy lifestyle is critical across all genetic risk groups.”

“Overall, the results indicate that a favorable lifestyle should be universally recommended in the prevention of type 2 diabetes, regardless of genetic predisposition, thus supporting current public health guidelines,”

Methods

We examined the joint association of genetic predisposition, obesity and unfavourable lifestyle with incident type 2 diabetes using a case-cohort study nested within the Diet, Cancer and Health cohort in Denmark. The study sample included 4729 individuals who developed type 2 diabetes during a median 14.7 years of follow-up, and a randomly selected cohort sample of 5402 individuals.

Results

Obesity (BMI ≥ 30 kg/m2) and unfavourable lifestyle were associated with higher risk for incident type 2 diabetes regardless of genetic predisposition (p > 0.05 for GRS–obesity and GRS–lifestyle interaction). The effect of obesity on type 2 diabetes risk (HR 5.81 [95% CI 5.16, 6.55]) was high, whereas the effects of high genetic risk (HR 2.00 [95% CI 1.76, 2.27]) and unfavourable lifestyle (HR 1.18 [95% CI 1.06, 1.30]) were relatively modest.

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Health: LVMH And Fashion Industry Now Making Hand Sanitizer, Masks And Protective Gear (Podcast)

Monocle 24 On Design LogoJamie Waters explains how the fashion industry emerged as a vital contributor in the fight against the pandemic. Many brands, big and small, have pivoted to make masks and other protective equipment.

Medical Economics: Virus Exposes America’s “Broken Healthcare System” (2020)

From The Guardian (April 16, 2020):

The Guardian Healthcare“As this epidemic makes clear, at any moment, any of us could become sick, could become hospitalized, could be on a mechanical ventilator,” said Adam Gaffney, an ICU doctor in Boston. “And that, in the United States, could mean potentially ruinous healthcare costs.”

With over 21,000 people dead and more than a 547,000 infected with the coronavirus in the US the last question on a person’s mind should be how they will pay for life-saving treatment.

There were 27.9 million people without health insurance in 2018, and record-high unemployment will increase that figure by millions

But as the death toll mounted, a patient who was about to be put on a ventilator in one of New York City’s stretched to capacity intensive care units had a final question for his nurse: “Who’s going to pay for it?”

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Health: Testing, Approving And Fairly Distributing A New Coronavirus Vaccine

SCIENTISTS ARE working at an unprecedented pace to find a vaccine for SARS-CoV-2, the virus that causes covid-19. The stakes are high. Natasha Loder, The Economist’s health policy editor, explains how an effective vaccine might be developed.

Dr Trevor Drew of the Australian Centre for Disease Preparedness speaks to host Kenneth Cukier about two trials which have reached the animal-testing stage. Plus, once a vaccine is discovered, what can be done to make sure it is distributed fairly? Dr Seth Berkely, chief executive of GAVI, the vaccine alliance, explains the importance of global cooperation. Runtime: 26 min

Social Distancing: 3-D Simulation Of How Respiratory Droplets Spread Coronavirus

From The New York Times (April 14, 2020):

Face Mask Disrupts trajectory of cough New York Times April 14 2020
Face Mask Disrupts trajectory of cough New York Times April 14 2020

But as this simulation suggests, and scientists have argued, droplets can travel farther than six feet. And small droplets known as aerosols can remain suspended or travel through the air before they eventually settle on surfaces. This is how they could disperse over the next 20 minutes.

The Centers for Disease Control and Prevention encourages people to stay home. If you must venture out, you should stay at least six feet away from others. The World Health Organization recommends a minimum of three feet of separation.

Scientists are learning about the novel coronavirus in real time, and those who study similar respiratory illnesses say that until it is better understood, no guideline is likely to offer perfect safety. Instead, understanding the possible transmission routes for the virus can help us see why keeping our distance is so important.

View 3-D simulation

Health Study: Physical Therapy Superior To Steroid Injection For Knee Osteoarthritis

New England Journal of Medicine Articles

Patients with osteoarthritis of the knee who underwent physical therapy had less pain and functional disability at 1 year than patients who received an intraarticular glucocorticoid injection.

Physical Therapy Superior To Glucocorticoid Injection for Knee Osteoarthritis NEJM April 9 2020

Osteoarthritis of the knee is a leading cause of disability.1 Current management is typically limited to the treatment of symptoms until late stages of arthritis lead to knee replacement.2 Intraarticular glucocorticoid injections are commonly used as a primary treatment for osteoarthritis of the knee,3 but there are conflicting reports regarding the extent and duration of the relief of symptoms with this therapy.4-6 Complications from these injections occur infrequently but include joint infection,7 accelerated degradation of articular cartilage,8 and subchondral insufficiency fractures.9

PHYSICAL THERAPY

The physical therapy intervention, which is described in the protocol,26 included instructions and images for exercises, joint mobilizations, and the clinical reasoning underlying the priorities, dosing, and progression of treatment. During a typical clinical session, the physical therapist would implement hands-on, manual techniques immediately before the patient performed reinforcing exercises to help the patient perform the movements with little or no pain. For example, if a patient could not fully extend or flex the knee, or those movements were painful, the physical therapist would use a hands-on, passive mobilizing technique to repeatedly move the knee to reduce stiffness while altering the mechanics of the technique to avoid pain. The patient would then perform repeated active knee movements in the same direction.

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Medical: Diagnosis And Treatment Of “Parkinson’s Disease” (JAMA Podcast)

JAMA Clinical Reviews LogoMore than 6 million people worldwide have Parkinson disease. Even though it is classically associated with tremors, the disease has many manifestations and is very treatable for most patients.

Michael S. Okun, MD, from the Department of Neurology at the University of Florida, Gainesville, discusses the pathophysiology, clinical presentation, diagnosis, and treatment of Parkinson disease.

Coronavirus/Covid-19: “Face Shields” Are Best In Preventing Transmission Says Epidemiologist

From web post by Michael B. Edmond (April 11, 2020):

Our goal should be to have a face shield for every person in the country. It should be worn anytime a person leaves their home, while in any public place, and even at work. From news reports, it appears that face shields are already being more commonly worn in other nations, particularly in some Asian countries. 

The advantages of face shields are their durability allowing them to be worn an indefinite number of times, the ability to easily clean them after use, their comfort, and they prevent the wearer from touching their face. Importantly, they cover all the portals of entry for this virus–the eyes, the nose, and the mouth. Moreover, the supply chain is significantly more diversified than that of face masks, so availability is much greater.

Some are critical of any strategy that isn’t perfect. But let’s think about the influenza vaccine. Although the effectiveness varies from year to year, on average it’s 40%. We push this vaccine hard in the hospital and in the community. Could we expect that face shields are at least 40% effective in reducing the transmission of COVID-19? I think so. Universal shielding would bend the curve more quickly and accelerate the ability to reduce social distancing and restrictions on movement.
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Face shields are a simple solution that if implemented universally would have a major impact on public health. Until we have a vaccine, this may be our best intervention for preventing transmission in the community.
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Michael B. Edmond, MD, MPH, MPA, MBA is the Chief Quality Officer and Associate Chief Medical Officer for University of Iowa Health Care and Clinical Professor of Infectious Diseases at the University of Iowa Carver College of Medicine. He previously served as the Richard P. Wenzel Professor of Internal Medicine, Chair of the Division of Infectious Diseases, and Hospital Epidemiologist at Virginia Commonwealth University in Richmond.

Coronavirus Policies: A Look At The Early Missteps By The CDC (Bloomberg)

Prognosis PodcastHistorically, the U.S. Centers for Disease control and Prevention has been the agency in charge of predicting, and containing outbreaks of disease. But as Covid 19 ravaged the country, the agency took a backseat to the White House. 

Michelle Fay Cortez and John Tozzi discuss how the agency has handled the pandemic response, its early missteps, and how its role is likely to change in the future.